A photo-responsive cholesterol capable of inducing a morphological transformation of the liquid-ordered microdomain in lipid bilayers

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An azobenzene-modified cholesterol was designed and synthesized for photo-induced domain transformation in lipid bilayer membranes. Upon UV-light irradiation, the cholesterol derivative changes the conformation through photoisomerization of the azobenzene moiety from trans- to cis-form. The photoisomerization effectively occurred both in liquid-ordered (Lo) and liquid-disordered (Ld) phases. Phase-contrast and fluorescence microscopic observation revealed that photoisomerization of the azobenzene-modified cholesterol induced the shape transformation of giant unilamellar vesicle (GUV) and the reorganization of Lo domain structure. Such a photo-induced transformation of lipid domain gave two different pathways dependent on the lipid composition of GUV; disappearance of the Lo domain or appearance of a small Ld domain with in the Lo domain.

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