Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
説明
<jats:title>Abstract</jats:title><jats:p>Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (<jats:italic>P</jats:italic><5 × 10<jats:sup>−8</jats:sup>), rs1116357 near <jats:italic>CCDC85A</jats:italic>, rs147538848 in <jats:italic>FAM60A</jats:italic>, rs1575972 near <jats:italic>DMRTA1</jats:italic>, rs9309245 near <jats:italic>ASB3</jats:italic>, rs67156297 near <jats:italic>ATP8B2</jats:italic>, rs7107784 near <jats:italic>MIR4686</jats:italic> and rs67839313 near <jats:italic>INAFM2</jats:italic>. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, <jats:italic>P</jats:italic><0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.</jats:p>
収録刊行物
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- Nature Communications
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Nature Communications 7 (1), 10531-, 2016-01-28
Springer Science and Business Media LLC
