During <i>Drosophila</i> disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay

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  • Tomonori Katsuyama
    Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, 4058 Basel, Switzerland;
  • Federico Comoglio
    Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, 4058 Basel, Switzerland;
  • Makiko Seimiya
    Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, 4058 Basel, Switzerland;
  • Erik Cabuy
    Single Cell Genomics, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; and
  • Renato Paro
    Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, 4058 Basel, Switzerland;

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<jats:title>Significance</jats:title> <jats:p> The larval imaginal discs of the fruit fly are capable of fully regenerating mechanically damaged parts. Wound healing is initiated by the JNK signaling pathway. We followed the subsequent formation of the regenerating blastema by transcriptome profiling and identified the JAK/STAT pathway as a central regulatory node controlling local cellular and global physiological responses. This signaling cascade induces, together with the Wingless pathway, proliferation of cells forming the blastema. However, JAK/STAT also up-regulates <jats:italic>Drosophila</jats:italic> insulin-like peptide 8 (Dilp8), a paracrine factor involved in organismal developmental delay, thereby allowing regenerative recovery. </jats:p>

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