Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys
-
- Takamichi Tohyama
- Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
-
- Masaharu Kinoshita
- Department of Physiology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan;
-
- Kenta Kobayashi
- Section of Viral Vector Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
-
- Kaoru Isa
- Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
-
- Dai Watanabe
- Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan;
-
- Kazuto Kobayashi
- Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan;
-
- Meigen Liu
- Department of Rehabilitation Medicine, Graduate School of Medicine, Keio University, Tokyo 160-8582, Japan;
-
- Tadashi Isa
- Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
Abstract
<jats:title>Significance</jats:title> <jats:p>There are different views about the targets of regenerative therapies to induce functional recovery in patients with motor paralysis following brain and spinal cord injury: whether we should aim at repairing the injured corticospinal tract or at facilitating compensation by other descending motor pathways. To help answer this question, we used double viral vectors to reversibly and selectively block the propriospinal neurons (PNs), one of the major intercalated neurons mediating cortical commands to motoneurons, in monkeys with partial spinal cord injury. We demonstrated causal roles of the PN-mediated pathway in promoting recovery of hand dexterity after the lesion. Thus, targeting the PNs might lead to developing effective treatment to facilitate recovery after spinal cord injury.</jats:p>
Journal
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 114 (3), 604-609, 2017-01-03
Proceedings of the National Academy of Sciences
- Tweet
Details 詳細情報について
-
- CRID
- 1360846642064374400
-
- ISSN
- 10916490
- 00278424
-
- Data Source
-
- Crossref
- KAKEN