Methodological standards for in vitro models of epilepsy and epileptic seizures. A <scp>TASK</scp>1‐<scp>WG</scp>4 report of the <scp>AES</scp>/<scp>ILAE</scp> Translational Task Force of the ILAE
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- Joseph V. Raimondo
- Division of Cell Biology Department of Human Biology Neuroscience Institute University of Cape Town Cape Town South Africa
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- Uwe Heinemann
- Neuroscience Research Center Charité Universitätsmedizin Berlin Berlin Germany
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- Marco de Curtis
- Epilepsy and Experimental Neurophysiology Unit The Foundation of the Carlo Besta Neurological Institute Milan Italy
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- Howard P. Goodkin
- Departments of Neurology and Pediatrics University of Virginia Charlottesville Virginia U.S.A
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- Chris G. Dulla
- Department of Neuroscience Tufts University School of Medicine Boston Massachusetts U.S.A
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- Damir Janigro
- Flocel Inc. Cleveland Ohio U.S.A
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- Akio Ikeda
- Department of Epilepsy, Movement Disorders, and Physiology Kyoto University Graduate School of Medicine Sakyo‐ku, Kyoto Japan
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- Chou‐Ching K. Lin
- Department of Neurology College of Medicine and Hospital National Cheng Kung University Tainan Taiwan
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- Premysl Jiruska
- Department of Developmental Epileptology Institute of Physiology Czech Academy of Sciences Prague Czech Republic
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- Aristea S. Galanopoulou
- Laboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience Albert Einstein College of Medicine Einstein/Montefiore Epilepsy Center, Montefiore Medical Center Bronx New York U.S.A
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- Christophe Bernard
- Inserm, Institut de Neurosciences des Systemes UMRS 1106 Aix Marseille University Marseille France
書誌事項
- 公開日
- 2017-11
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#am
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/epi.13901
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Summary</jats:title><jats:p>In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.</jats:p>
収録刊行物
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- Epilepsia
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Epilepsia 58 (S4), 40-52, 2017-11
Wiley