Regio- and Stereoselectivity of the Intramolecular C–H Insertion by Cyclopropylidenes Bearing a Remote Oxido Substituent

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公開日
1987-05-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1246/bcsj.60.1715
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>(ω-Oxidoalkyl)cyclopropylidenes generated from (2,2-dibromo-1-methylcyclopropyl)-CH2–X–(CH2)n–OH (X=CH2 or O, n=1, 2) by the reaction with methyllithium underwent a regioselective intramolecular insertion into the C–H bond at the δ position to the carbenic carbon. The activation effect of the oxido substituent on the reactivity of C–H bonds is discussed on the basis of (1) the ratio of the insertion products to the rearrangement product allenyl alcohol, and (2) the endo stereoselectivity of the present insertion reactions.</jats:p>

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