Biocompatible Nanoparticle Based on Dextran-<i>b</i>-Poly(<scp>l</scp>-lactide) Block Copolymer Formed by Flash Nanoprecipitation

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  • Mingwei Wang
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Yisheng Xu
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Jie Wang
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Miaomiao Liu
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Zhenyu Yuan
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Kai Chen
    School of Chemistry and Chemical Engineering, Shihezi University
  • Li Li
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology
  • Robert K Prud’homme
    Department of Chemical and Biological Engineering, Princeton University
  • Xuhong Guo
    State Key Laboratory of Chemical Engineering, East China University of Science and Technology

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説明

<jats:title>Abstract</jats:title> <jats:p>Biocompatible amphiphilic block copolymer dextran-b-poly(l-lactide) was synthesized by the end-to-end coupling of amino-terminated dextran and acryloyl-terminated poly(l-lactide). The dextran block copolymer was used to rapidly prepare nanoparticles encapsulating β-carotene through flash nanoprecipitation. The nanoparticle size can be tuned by different solvent ratios and stream velocities. The nanoparticles could be stably preserved for more than half a month, and an “anti-Ostwald” phenomenon was observed in the first week. The results indicate that flash nanoprecipitation is a promising method to prepare polysaccharide nanoparticles as drug carriers.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 44 (12), 1688-1690, 2015-10-03

    Oxford University Press (OUP)

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