Elastin-Based Silver-Binding Proteins with Antibacterial Capabilities
-
- Truong Thi Hong Anh
- School of Materials Science & Engineering, Nanyang Technological University, Singapore
-
- Ma Xing
- School of Materials Science & Engineering, Nanyang Technological University, Singapore
-
- Duc Huynh Tien Le
- Department of Chemical System Engineering, University of Tokyo, Tokyo, Japan
-
- Ayae Sugawara-Narutaki
- Department of Chemical System Engineering, University of Tokyo, Tokyo, Japan
この論文をさがす
説明
To develop novel elastin-like materials with antibacterial capabilities.Artificial proteins bearing AG3 silver-binding motifs (GPG-AG3) were constructed using genetic engineering. GPG-AG3 materials were prepared as GPG-AG3 protein aggregates as well as chemically crosslinked spin-coated thin films. Both GPG-AG3 protein aggregates and thin films were incubated in silver nitrate solution and characterized using electron microscopy.The GPG-AG3 substrates prepared in this work have the ability to nucleate silver under physiological conditions. When tested against gram-negative Escherichia coli bacterial culture, silver-coated GPG-AG3 materials were able to inhibit bacterial growth, confirming their antibacterial properties.Antibacterial artificial protein materials were successfully developed, demonstrating promise for use as wound dressings and biomedical implant coatings.
収録刊行物
-
- Nanomedicine
-
Nanomedicine 8 (4), 567-575, 2013-04
Informa UK Limited
