Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline
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- Naoki Tani
- Departments of Neurosurgery and
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- Haruhiko Kishima
- Departments of Neurosurgery and
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- Hui Ming Khoo
- Departments of Neurosurgery and
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- Takufumi Yanagisawa
- Departments of Neurosurgery and
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- Satoru Oshino
- Departments of Neurosurgery and
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- Tomoyuki Maruo
- Departments of Neurosurgery and
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- Koichi Hosomi
- Departments of Neurosurgery and
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- Masayuki Hirata
- Departments of Neurosurgery and
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- Hiroaki Kazui
- Psychiatry, Osaka University Graduate School of Medicine, Suita;
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- Keiko Tokumasu Nomura
- Psychiatry, Osaka University Graduate School of Medicine, Suita;
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- Mohamed M. Aly
- Department of Neurosurgery, Mansoura University Hospital, Mansoura, Egypt
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- Amami Kato
- Department of Neurosurgery, Kinki University School of Medicine, Osaka-Sayama, Japan; and
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- Toshiki Yoshimine
- Departments of Neurosurgery and
抄録
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Epilepsy surgery is of known benefit for drug-resistant temporal lobe epilepsy (TLE); however, a certain number of patients suffer significant decline in verbal memory after hippocampectomy. To prevent this disabling complication, a reliable test for predicting postoperative memory decline is greatly desired. Therefore, the authors assessed the value of electrical stimulation of the parahippocampal gyrus (PHG) as a provocation test of verbal memory decline after hippocampectomy on the dominant side.</jats:p></jats:sec> <jats:sec> <jats:title>METHODS</jats:title> <jats:p>Eleven right-handed, Japanese-speaking patients with medically intractable left TLE participated in the study. Before surgery, they underwent provocative testing via electrical stimulation of the left PHG during a verbal encoding task. Their pre- and posthippocampectomy memory function was evaluated according to the Wechsler Memory Scale-Revised (WMS-R) and/or Mini-Mental State Examination (MMSE) before and 6 months after surgery. The relationship between postsurgical memory decline and results of the provocative test was evaluated.</jats:p></jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Left hippocampectomy was performed in 7 of the 11 patients. In 3 patients with a positive provocative recognition test, verbal memory function, as assessed by the WMS-R, decreased after hippocampectomy, whereas in 4 patients with a negative provocative recognition test, verbal memory function, as assessed by the WMS-R or MMSE, was preserved.</jats:p></jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Results of the present study suggest that electrical stimulation of the PHG is a reliable provocative test to predict posthippocampectomy verbal memory decline.</jats:p></jats:sec>
収録刊行物
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- Journal of Neurosurgery
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Journal of Neurosurgery 125 (5), 1053-1060, 2016-11
Journal of Neurosurgery Publishing Group (JNSPG)
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詳細情報 詳細情報について
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- CRID
- 1360846645506779264
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- ISSN
- 19330693
- 00223085
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- データソース種別
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- Crossref
- KAKEN