Clinical Utility of YKL-40 in Polymyositis/dermatomyositis-associated Interstitial Lung Disease
説明
<jats:sec><jats:title>Objective.</jats:title><jats:p>Interstitial lung disease (ILD) is involved in polymyositis/dermatomyositis (PM/DM), a disease associated with poor prognoses. Chitinase-3-like-1 protein (YKL-40) has pleiotropic biological activities involved in inflammation, cell proliferation, and tissue remodeling; however, the clinical application of YKL-40 remains limited. We investigated the clinical significance of YKL-40 in PM/DM–ILD.</jats:p></jats:sec><jats:sec><jats:title>Methods.</jats:title><jats:p>Sixty-nine consecutive patients with PM/DM–ILD and 34 healthy controls were analyzed. We measured baseline and followup serum YKL-40 using an ELISA, evaluated the association of YKL-40 with clinical variables and survival, and examined YKL-40 expression in lung specimens from patients with PM/DM–ILD using immunohistochemistry.</jats:p></jats:sec><jats:sec><jats:title>Results.</jats:title><jats:p>Serum YKL-40 levels were significantly greater in patients with PM/DM–ILD compared with healthy controls (p < 0.0001). Serum YKL-40 was correlated with arterial oxygen pressure (r = –0.40, p < 0.001) and percent-predicted DLCO (r = –0.41, p = 0.01) in patients with PM/DM–ILD. Multivariate Cox hazard analysis demonstrated that higher serum YKL-40 and lower percent-predicted forced vital capacity were independently associated with a poor prognosis. Immunohistochemistry analysis demonstrated that YKL-40 expression was enhanced in aggregated intraalveolar macrophages and hyperproliferative alveolar epithelial cells in patients with PM/DM–ILD.</jats:p></jats:sec><jats:sec><jats:title>Conclusion.</jats:title><jats:p>YKL-40 is a promising biomarker for evaluating PM/DM–ILD activity/severity and predicting disease prognosis. Insights into YKL-40 might help elucidate the pathogenesis of PM/DM–ILD.</jats:p></jats:sec>
収録刊行物
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- The Journal of Rheumatology
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The Journal of Rheumatology 44 (9), 1394-1401, 2017-07-15
The Journal of Rheumatology