Membrane dynamics in mammalian embryogenesis: Implication in signal regulation

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  • Yoh Wada
    Division of Biological Sciences Institute of Scientific and Industrial Research, Osaka University Mihogaoka 8‐1, Ibaraki Osaka 567‐0047 Japan
  • Ge‐Hong Sun‐Wada
    Department of Biochemistry Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo Kyotanabe Kyoto 610‐0395 Japan
  • Nobuyuki Kawamura
    Department of Biochemistry Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo Kyotanabe Kyoto 610‐0395 Japan
  • Jyunichiro Yasukawa
    Department of Biochemistry Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo Kyotanabe Kyoto 610‐0395 Japan

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<jats:title>Abstract</jats:title><jats:p>Eukaryotes have evolved an array of membrane compartments constituting secretory and endocytic pathways that allow the flow of materials. Both pathways perform important regulatory roles. The secretory pathway is essential for the production of extracellular, secreted signal molecules, but its function is not restricted to a mere route connecting intra‐ and extracellular compartments. Post‐translational modifications also play an integral function in the secretory pathway and are implicated in developmental regulation. The endocytic pathway serves as a platform for relaying signals from the extracellular stimuli to intracellular mediators, and then ultimately inducing signal termination. Here, we discuss recent studies showing that dysfunction in membrane dynamics causes patterning defects in embryogenesis and tissue morphogenesis in mammals. Birth Defects Research (Part C) 108:33–44, 2016. © 2016 Wiley Periodicals, Inc.</jats:p>

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