Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan

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  • Shoji Kubo
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Yasuni Nakanuma
    Department of Human Pathology; Kanazawa University Graduate School of Medicine; Kanazawa Japan
  • Shigekazu Takemura
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Chikaharu Sakata
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Yorihisa Urata
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Akinori Nozawa
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Takayoshi Nishioka
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Masahiko Kinoshita
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Genya Hamano
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka City University Graduate School of Medicine; 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585 Japan
  • Hiroaki Terajima
    Department of Gastroenterological Surgery and Oncology; Kitano Hospital; Tazuke Kofukai Medical Institute; Osaka Japan
  • Gorou Tachiyama
    Department of Surgery; Tane General Hospital; Osaka Japan
  • Yuji Matsumura
    Department of Gastroenterology; Juntendo University; Tokyo Japan
  • Terumasa Yamada
    Department of Surgery; Osaka Medical Center for Cancer and Cardiovascular Diseases; Osaka Japan
  • Hiromu Tanaka
    Department of Surgery; Higashisumiyoshi-Morimoto Hospital; Osaka Japan
  • Shoji Nakamori
    Department of Surgery; National Hospital Organization; Osaka National Hospital; Osaka Japan
  • Akira Arimoto
    Department of Hepato-Biliary-Pancreatic Surgery; Osaka Red Cross Hospital; Osaka Japan
  • Norifumi Kawada
    Department of Hepatology; Osaka City University Graduate School of Medicine; Osaka Japan
  • Masahiro Fujikawa
    Department of Surgery; Nissey Hospital; Osaka Japan
  • Hiromitsu Fujishima
    Department of Digestive Disease and Oncology; National Hospital Organization; Kagoshima Medical Center; Kagoshima Japan
  • Yasuhiko Sugawara
    Artificial Organ & Transplantation Division; Department of Surgery; University of Tokyo; Tokyo Japan
  • Shogo Tanaka
    Department of Surgery; Ishikiriseiki Hospital; Osaka Japan
  • Hideyoshi Toyokawa
    Department of Surgery; Kansai Medical University; Osaka Japan
  • Yuko Kuwae
    Department of Diagnostic Pathology; Osaka City University Graduate School of Medicine; Osaka Japan
  • Masahiko Ohsawa
    Department of Diagnostic Pathology; Osaka City University Graduate School of Medicine; Osaka Japan
  • Shinichiro Uehara
    Department of Preventive Medicine and Environmental Health; Osaka City University Graduate School of Medicine; Osaka Japan
  • Kyoko Kogawa Sato
    Department of Preventive Medicine and Environmental Health; Osaka City University Graduate School of Medicine; Osaka Japan
  • Tomoshige Hayashi
    Department of Preventive Medicine and Environmental Health; Osaka City University Graduate School of Medicine; Osaka Japan
  • Ginji Endo
    Department of Preventive Medicine and Environmental Health; Osaka City University Graduate School of Medicine; Osaka Japan

書誌事項

公開日
2014-01-13
資源種別
journal article
権利情報
  • http://doi.wiley.com/10.1002/tdm_license_1.1
DOI
  • 10.1002/jhbp.86
公開者
Wiley

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説明

An outbreak of cholangiocarcinoma occurred among workers in the offset color proof-printing department at a printing company in Japan. The aim of this study was to clarify the characteristics of the patients with cholangiocarcinoma.This was a retrospective study conducted in 13 Japanese hospitals between 1996 to 2013. The clinicopathological findings of cholangiocarcinoma developed in 17 of 111 former or current workers in the department were investigated. Most workers were relatively young.The cholangiocarcinoma was diagnosed at 25-45 years old. They were exposed to chemicals, including dichloromethane and 1,2-dichloropropane. The serum γ-glutamyl transpeptidase activity was elevated in all patients. Dilated intrahepatic bile ducts without tumor-induced obstruction were observed in five patients. The cholangiocarcinomas arose from the large bile ducts. The precancerous or early cancerous lesions, such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile ducts, as well as non-specific bile duct injuries, such as fibrosis, were observed in various sites of the bile ducts in all eight patients for whom operative specimens were available.The present results showed that cholangiocarcinomas occurred at a high incidence in relatively young workers of a printing company, who were exposed to chemicals including chlorinated organic solvents.

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