Supermolecular drug challenge to overcome drug resistance in cancer cells
書誌事項
- 公開日
- 2018-08
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
-
- 10.1016/j.drudis.2018.05.037
- 公開者
- Elsevier BV
この論文をさがす
説明
Overcoming multidrug resistance (MDR) of cancer cells can be accomplished using drug delivery systems in large-molecular-weight ATP-binding cassette transporters before entry into phagolysosomes and by particle-cell-surface interactions. However, these hypotheses do not address the intratumoral heterogeneity in cancer. Anti-MDR must be related to alterations of drug targets, expression of detoxification, as well as altered proliferation. In this study, it is shown that the excellent efficacy and sustainability of anti-MDR is due to a stable ES complex because of the allosteric facilities of artificial enzymes when they are used as supermolecular complexes. The allosteric effect of supermolecular drugs can be explained by the induced-fit model and can provide stable feedback control systems through the loop transfer function of the Hill equation.
収録刊行物
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- Drug Discovery Today
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Drug Discovery Today 23 (8), 1556-1563, 2018-08
Elsevier BV
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キーワード
- Drug Carriers
- Molecular Structure
- Paclitaxel
- Drug Compounding
- Melanoma, Experimental
- Antineoplastic Agents
- Dextrans
- Models, Biological
- Drug Resistance, Multiple
- Mice
- Structure-Activity Relationship
- Allosteric Regulation
- Drug Resistance, Neoplasm
- Tumor Microenvironment
- Animals
- Methylmethacrylates
- ATP-Binding Cassette Transporters
詳細情報 詳細情報について
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- CRID
- 1360848657029792000
-
- ISSN
- 13596446
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- PubMed
- 29879476
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- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
