Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas
書誌事項
- 公開日
- 2014-04
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- http://www.elsevier.com/open-access/userlicense/1.0/
- DOI
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- 10.1016/j.fertnstert.2013.12.049
- 公開者
- Elsevier BV
この論文をさがす
説明
To evaluate the effects of endometriomas on the regulation of early follicular development.Histologic analysis of prospectively collected biopsy samples.Research unit in a university hospital.Women <40 years of age who have ovarian endometriomas.Biopsy of healthy cortex from ovaries affected by endometriomas (≤ 4 cm) and contralateral ovaries without cysts.Histomorphological staging of early follicles, measurement of follicle, oocyte, and oocyte nucleus diameters, immunohistochemistry of proliferating cell nuclear antigen, and caspase-3.Thirteen cortical samples from ovaries with endometriomas and 13 samples from contralateral ovaries without endometriomas were evaluated. Cortex from ovaries with endometriomas contained significantly more morphologically atretic early follicles than cortex from contralateral ovaries without cysts. These follicles showed cleaved caspase-3 immunostaining. Diameters of primordial follicles and oocytes were decreased in cortex from ovaries with endometriomas, whereas early follicles with proliferating cell nuclear antigen-positive granulosa cells (GCs) were significantly increased in number.Ovaries with endometriomas, which may be more prone to local pelvic inflammation, showed activated follicular recruitment and atresia of early follicles. The potential contribution of inflammation to follicle "burnout" in case of endometriomas is discussed.
収録刊行物
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- Fertility and Sterility
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Fertility and Sterility 101 (4), 1031-1037, 2014-04
Elsevier BV