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説明
Abstract The first enantioselective total synthesis of JBIR-03 and asporyzin C, indole diterpenoids of fungal origin exhibiting a range of pharmacologically important biological activities, has been accomplished from a known bicyclic keto alcohol in 13 and 14 steps, respectively. A hydroxy-directed cyclopropanation and Pd(II)-mediated indole ring formation were exploited as the key steps to obtain a pivotal pentacylic intermediate, which was converted into asporyzin C via chain elongation using cross-metathesis and then into JBIR-03 by Pd(II)-catalyzed tetrahydrofuran ring formation in an exclusively diastereoselective manner.
収録刊行物
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- Tetrahedron Letters
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Tetrahedron Letters 59 (46), 4107-4109, 2018-11
Elsevier BV
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詳細情報 詳細情報について
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- CRID
- 1360848657458254208
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- ISSN
- 00404039
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE