DNA Photo-cross-linking Using Pyranocarbazole and Visible Light

  • Kenzo Fujimoto
    Department of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Asahidai 1-1, Nomi, Ishikawa, 923-1292, Japan
  • Shinobu Sasago
    Department of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Asahidai 1-1, Nomi, Ishikawa, 923-1292, Japan
  • Junichi Mihara
    Department of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Asahidai 1-1, Nomi, Ishikawa, 923-1292, Japan
  • Shigetaka Nakamura
    Department of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Asahidai 1-1, Nomi, Ishikawa, 923-1292, Japan

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Description

This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.

Journal

  • Organic Letters

    Organic Letters 20 (10), 2802-2805, 2018-04-27

    American Chemical Society (ACS)

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