Total synthesis of COPD biomarker desmosine that crosslinks elastin
書誌事項
- 公開日
- 2012
- 資源種別
- journal article
- DOI
-
- 10.1039/c2cc17958j
- 10.1002/chin.201229212
- 公開者
- Royal Society of Chemistry (RSC)
この論文をさがす
説明
Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing stepwise and regioselective Sonogashira cross-coupling reactions.
収録刊行物
-
- Chemical Communications
-
Chemical Communications 48 (26), 3233-, 2012
Royal Society of Chemistry (RSC)