Spatiotemporal Analysis of Simultaneous Repetitive Electrical Stimulation with Voltage Sensitive Dye
説明
In visual prostheses, resolution of restored image remain a matter of concern. The most common strategy is mainly focused on enhancing the hardware capabilities of the prosthetic devices, e.g., the density of stimulating electrodes. However, it is not yet well understood how electrical stimulations delivered from multiple electrodes interact spatially and temporally. We conducted intracortical microstimulation in mice using a pair of glass electrodes inserted in the primary visual cortex and recorded the cortical responses using voltage-sensitive dye imaging, which allowed us a fairly good spatial and temporal resolution. Response induced by simultaneous stimulation of both electrodes was compared to linear off-line summation of individual stimulation responses. We found an enhancing effect of simultaneous stimulation in a weak intensity range (≤ 10 μA) and a suppressive effect in a high intensity range, compared to the linear summation of responses. Also, cortical responses to simultaneous stimulation were found to merge in the first tens of milliseconds after simultaneous stimulation on-set and gradually regress back to the stimulation sites. The results obtained in the present study provide a physiological basis for controlling electrical activities to improve spatial resolution of restored image, such as it is done in current steering.
収録刊行物
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- 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) 1-4, 2018-10
IEEE
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詳細情報 詳細情報について
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- CRID
- 1360848660089843456
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE