Distribution of myofibroblast and tenascin‐<scp>C</scp> in cystic adventitial disease: Comparison with ganglion
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- Hiroyuki Hao
- Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan
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- Hatsue Ishibashi‐Ueda
- Department of Pathology National Cerebral and Cardiovascular Center Suita Osaka Japan
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- Naoki Nishida
- Department of Pathology National Cerebral and Cardiovascular Center Suita Osaka Japan
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- Rika Kawakami
- Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan
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- Yoshitane Tsukamoto
- Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan
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- Masahiko Tsujimoto
- Department of Pathology Osaka Police Hospital Osaka City Osaka Japan
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- Seiichi Hirota
- Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan
この論文をさがす
説明
<jats:p>Cystic adventitial disease (<jats:styled-content style="fixed-case">CAD</jats:styled-content>) is a rare peripheral artery disorder which shows the development of gelatinous cysts in the adventitia. Although several theories for the pathogenesis of <jats:styled-content style="fixed-case">CAD</jats:styled-content> have been postulated, the etiology of <jats:styled-content style="fixed-case">CAD</jats:styled-content> remains unclear. Histological examination of three <jats:styled-content style="fixed-case">CAD</jats:styled-content> cases revealed that these cyst walls were composed of fibrous tissue and lacked both epithelial and endothelial lining. The surfaces of these cysts were partially covered with spindle‐shaped cells, similar to the interstitial cells within the cyst wall. A pool of mucinous material in the adventitia was evident. Distribution of vimentin‐positive spindle‐shaped cells and scattered <jats:styled-content style="fixed-case">CD</jats:styled-content>68‐positive oval‐shaped cells in the cyst wall was revealed by immunohistochemistry. A part of vimentin‐positive spindle‐shaped cells demonstrated to be positive for α‐smooth muscle actin, indicating the presence of myofibroblasts in the cyst wall. A focal tenascin‐<jats:styled-content style="fixed-case">C</jats:styled-content>‐positive area was observed in the cyst wall of our <jats:styled-content style="fixed-case">CAD</jats:styled-content> cases. Presence of two different cell types, proliferation of myofibroblasts and expression of tenascin‐<jats:styled-content style="fixed-case">C</jats:styled-content> were consistent with those of cyst walls of 20 surgically resected ganglions. These results suggest that <jats:styled-content style="fixed-case">CAD</jats:styled-content> may arise as capsular synovial structures, similar to ganglion cysts.</jats:p>
収録刊行物
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- Pathology International
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Pathology International 63 (12), 591-598, 2013-12
Wiley
