<jats:sec><jats:title>Background</jats:title><jats:p> The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson’s disease (PD) is a controversial issue. </jats:p></jats:sec><jats:sec><jats:title>Purpose</jats:title><jats:p> To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p> In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e.g. GDS-15, Mini-Mental State Examination, PD duration, age, sex). Statistical Parametric Mapping 8 software was used for image gray matter segmentation and for a correlation analysis between gray matter volume and GDS-15 score. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> The results showed a significant negative correlation between GDS-15 score and left hippocampal volume, and between GDS-15 score and right parahippocampal gyrus volume. No significant positive correlations were found in the whole brain. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> The current results provide new evidence regarding the relationship between depression in PD and hippocampal volume. </jats:p></jats:sec>