Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination
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- Yasushi Akahori
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Linan Wang
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Motohiro Yoneyama
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Naohiro Seo
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Satoshi Okumura
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Yoshihiro Miyahara
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Yasunori Amaishi
- Takara Bio Inc., Shiga, Japan;
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- Sachiko Okamoto
- Takara Bio Inc., Shiga, Japan;
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- Junichi Mineno
- Takara Bio Inc., Shiga, Japan;
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- Hiroaki Ikeda
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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- Takehiro Maki
- Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Hokkaido, Japan;
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- Hiroshi Fujiwara
- Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan;
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- Yoshiki Akatsuka
- Department of Hematology and Oncology, Fujita Health University, Toyoake, Aichi, Japan;
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- Takuma Kato
- Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, Mie, Japan; and
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- Hiroshi Shiku
- Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;
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説明
<jats:title>Key Points</jats:title><jats:p>T cells expressing a CAR consisting of scFv #213 targeting WT1 peptide/HLA-A*2402 complex killed HLA-A*2402+ WT1+ tumor cell lines. The therapeutic efficacy of #213 scFv CAR-T cells was shown to be enhanced by DC vaccine in a murine xenograft model.</jats:p>
収録刊行物
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- Blood
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Blood 132 (11), 1134-1145, 2018-09-13
American Society of Hematology