Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities
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- Terunobu Fukuda
- Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
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- Kanoko Kominami
- Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
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- Shujie Wang
- Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
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- Hideru Togashi
- Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
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- Ken-ichi Hirata
- Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
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- Akira Mizoguchi
- Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
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- Yoshiyuki Rikitake
- Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
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- Yoshimi Takai
- Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
書誌事項
- 公開日
- 2014-01-15
- 資源種別
- journal article
- DOI
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- 10.1242/dev.094995
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:p>The organ of Corti consists of sensory hair cells (HCs) interdigitated with nonsensory supporting cells (SCs) to form a checkerboard-like cellular pattern. HCs are equipped with hair bundles on their apical surfaces. We previously reported that cell-adhesive nectins regulate the checkerboard-like cellular patterning of HCs and SCs in the mouse auditory epithelium. Nectin-1 and -3 are differentially expressed in normal HCs and SCs, respectively, and in Nectin-3-deficient mice a number of HCs are aberrantly attached to each other. We show here that these aberrantly attached HCs in Nectin-3-deficient mice, but not unattached ones, show disturbances of the orientation and morphology of the hair bundles and the positioning of the kinocilium, with additional abnormal localisation of cadherin-catenin complexes and the apical-basal polarity proteins Pals1 and Par-3. These results indicate that, owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology.</jats:p>
収録刊行物
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- Development
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Development 141 (2), 399-409, 2014-01-15
The Company of Biologists
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キーワード
- Mice, Knockout
- Nectins
- Labyrinth Supporting Cells
- Cell Polarity
- Gene Expression Regulation, Developmental
- Membrane Proteins
- Frizzled Receptors
- Mice
- Intercellular Junctions
- Microscopy, Electron, Transmission
- Pregnancy
- Hair Cells, Auditory
- Cell Adhesion
- Microscopy, Electron, Scanning
- Animals
- Female
- Carrier Proteins
- Cell Adhesion Molecules
- Organ of Corti
詳細情報 詳細情報について
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- CRID
- 1360848661908154112
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- ISSN
- 14779129
- 09501991
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- PubMed
- 24381198
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
