IKKε inhibits PKC to promote Fascin-dependent actin bundling
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- Yosuke Ogura
- RIKEN Center for Developmental Biology 1 Laboratory for Morphogenetic Signaling , , Kobe, Hyogo 650-0047 , Japan
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- Kazuyo Misaki
- RIKEN Center for Developmental Biology 2 Electron Microscope Laboratory , , Kobe, Hyogo 650-0047 , Japan
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- Shigenobu Yonemura
- RIKEN Center for Developmental Biology 2 Electron Microscope Laboratory , , Kobe, Hyogo 650-0047 , Japan
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- Shigeo Hayashi
- RIKEN Center for Developmental Biology 1 Laboratory for Morphogenetic Signaling , , Kobe, Hyogo 650-0047 , Japan
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- Takuya Maeda
- RIKEN Center for Developmental Biology 1 Laboratory for Morphogenetic Signaling , , Kobe, Hyogo 650-0047 , Japan
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- Akiyo Kimpara
- RIKEN Center for Developmental Biology 1 Laboratory for Morphogenetic Signaling , , Kobe, Hyogo 650-0047 , Japan
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- Tetsuhisa Otani
- RIKEN Center for Developmental Biology 1 Laboratory for Morphogenetic Signaling , , Kobe, Hyogo 650-0047 , Japan
書誌事項
- 公開日
- 2016-10-15
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/3.0
- DOI
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- 10.1242/dev.138495
- 10.1242/jcs.198556
- 公開者
- The Company of Biologists
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説明
<jats:p>Signaling molecules have pleiotropic functions and are activated by various extracellular stimuli. Protein kinase C (PKC) is activated by diverse receptors, and its dysregulation is associated with diseases including cancer. However, how the undesired activation of PKC is prevented during development remains poorly understood. We have previously shown that a protein kinase, IKKε, is active at the growing bristle tip and regulates actin bundle organization during Drosophila bristle morphogenesis. Here, we demonstrate that IKKε regulates the actin bundle localization of a dynamic actin cross-linker, Fascin. IKKε inhibits PKC, thereby protecting Fascin from inhibitory phosphorylation. Excess PKC activation is responsible for the actin bundle defects in IKKε-deficient bristles, whereas PKC is dispensable for bristle morphogenesis in wild-type bristles, indicating that PKC is repressed by IKKε in wild-type bristle cells. These results suggest that IKKε prevents excess activation of PKC during bristle morphogenesis.</jats:p>
収録刊行物
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- Development
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Development 143 (20), 3806-3816, 2016-10-15
The Company of Biologists
