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Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway
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- Yuanyuan Li
- Life Science Research Institute, Saga Medical Center Koseikan, Saga, Japan
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- Miki Ohira
- Division of Cancer Genomics, Chiba Cancer Center Research Institute, Chiba, Japan
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- Yong Zhou
- BGI-Shenzhen, Shenzhen, China
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- Teng Xiong
- BGI-Shenzhen, Shenzhen, China
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- Wen Luo
- BGI-Shenzhen, Shenzhen, China
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- Chao Yang
- BGI-Shenzhen, Shenzhen, China
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- Xiangchun Li
- BGI-Shenzhen, Shenzhen, China
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- Zhibo Gao
- BGI-Shenzhen, Shenzhen, China
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- Rui Zhou
- BGI-Shenzhen, Shenzhen, China
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- Yohko Nakamura
- Division of Biochemistry and Innovative Cancer Therapy, Chiba Cancer Center Research Institute, Chiba, Japan
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- Takehiko Kamijo
- Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
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- Yasuhiko Kaneko
- Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
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- Takeshi Taketani
- Department of Pediatrics, Shimane University School of Medicine, Shimane, Japan
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- Junichi Ueyama
- Division of Pediatrics and Perinatology, Tottori University School of Medicine, Tottori, Japan
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- Tatsuro Tajiri
- Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
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- Hongyan Zhang
- BGI-Shenzhen, Shenzhen, China
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- Jian Wang
- BGI-Shenzhen, Shenzhen, China
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- Huanming Yang
- BGI-Shenzhen, Shenzhen, China
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- Ye Yin
- BGI-Shenzhen, Shenzhen, China
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- Akira Nakagawara
- Life Science Research Institute, Saga Medical Center Koseikan, Saga, Japan
Description
Neuroblastoma (NB) is a childhood solid malignant tumor originating from precursor cells of the peripheral nervous system. We have previously established a risk classification system based on DNA copy number profiles. To further explore the pathogenesis of NBs in distinct risk groups, we performed whole-exome sequencing analysis of 57 primary and 7 recurrent/metastatic tumors with unique chromosomal aberration profiles as categorized by our genomic sub-grouping system. Overall, a low frequency of somatic mutations was found. Besides
Journal
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- Oncotarget
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Oncotarget 8 (34), 56684-56697, 2017-05-23
Impact Journals, LLC
