Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury
説明
Functional loss of limb control in individuals with spinal cord injury or stroke can be caused by interruption of corticospinal pathways, although the neural circuits located above and below the lesion remain functional. An artificial neural connection that bridges the lost pathway and connects cortical to spinal circuits has potential to ameliorate the functional loss. We investigated the effects of introducing novel artificial neural connections in a paretic monkey that had a unilateral spinal cord lesion at the C2 level. The first application bridged the impaired spinal lesion. This allowed the monkey to drive the spinal stimulation through volitionally controlled power of high-gamma activity in either the premotor or motor cortex, and thereby to acquire a force-matching target. The second application created an artificial recurrent connection from a paretic agonist muscle to a spinal site, allowing muscle-controlled spinal stimulation to boost on-going activity in the muscle. These results suggest that artificial neural connections can compensate for interrupted descending pathways and promote volitional control of upper limb movement after damage of descending pathways such as spinal cord injury or stroke.
収録刊行物
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- Frontiers in Neural Circuits
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Frontiers in Neural Circuits 7 57-, 2013
Frontiers Media SA
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キーワード
- Male
- muscle
- Movement
- Pyramidal Tracts
- Neurosciences. Biological psychiatry. Neuropsychiatry
- Upper Extremity
- Animals
- Spinal Cord Injuries
- local field potential
- artificial neural connection
- brain–computer interface
- spinal cord
- Brain Computer Interface
- Recovery of Function
- Hand
- spinal cord injury
- Electric Stimulation
- Electrodes, Implanted
- Muscle
- hand
- monkey
- Macaca nemestrina
- Psychomotor Performance
- RC321-571
- Neuroscience
詳細情報 詳細情報について
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- CRID
- 1360848664379181056
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- ISSN
- 16625110
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- PubMed
- 23596396
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
