Inhibitory Effects of Hybrid Liposomes on the Growth of Non-small Cell Lung Carcinoma Cells and Anti-invasive Activity by Ceramide Generation without any Drugs

DOI オープンアクセス

書誌事項

公開日
2015
資源種別
journal article
DOI
  • 10.4172/2157-2518.1000230
公開者
OMICS Publishing Group

説明

Ceramide generation and invasive inhibition by hybrid liposomes (HL) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene (23) dodecyl ether (C12(EO)23) were examined for human lung cancer (A549) cells in vitro. Ceramide generation for A549 cells treated with HL was observed through the activation of neutral sphingomyelinase. These was a reduction in sphingomyelin in A549 cells after treatment with HL. The anti-invasive effects of HL for A549 cells were obtained through the inhibition of MT1MMP/MMP14. Inhibitory effects of HL on the migration of A549 cells was obtained using scratch assay.

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詳細情報 詳細情報について

  • CRID
    1360848664894834048
  • DOI
    10.4172/2157-2518.1000230
  • ISSN
    21572518
  • 資料種別
    journal article
  • データソース種別
    • Crossref
    • KAKEN
    • OpenAIRE

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