One-step Preparation of N-Unprotected Aziridines from 2<i>H</i>-Azirines by Addition of Ketene Silyl Acetals Catalyzed by Lewis Acids
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- Itaru Suzuki
- Research Center for Environmental Preservation, Osaka University, 2-4 Yamada-oka, Suita, Osaka 565-0871 , Japan
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- Yuya Takenaka
- Research Center for Environmental Preservation, Osaka University, 2-4 Yamada-oka, Suita, Osaka 565-0871 , Japan
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- Yoshitaka Morishita
- Research Center for Environmental Preservation, Osaka University, 2-4 Yamada-oka, Suita, Osaka 565-0871 , Japan
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- Ikuya Shibata
- Research Center for Environmental Preservation, Osaka University, 2-4 Yamada-oka, Suita, Osaka 565-0871 , Japan
抄録
<jats:title>Abstract</jats:title> <jats:p>The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then be transformed into either oxazolines or γ–amino carbonyls.</jats:p>
収録刊行物
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- Chemistry Letters
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Chemistry Letters 51 (1), 9-12, 2021-10-14
Oxford University Press (OUP)
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詳細情報 詳細情報について
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- CRID
- 1360853498616941696
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- NII論文ID
- 130008137578
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- ISSN
- 13480715
- 03667022
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