Lipopolysaccharides transport during fat absorption in rodent small intestine

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  • Yasutada Akiba
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California
  • Koji Maruta
    Department of Medicine, University of California, School of Medicine, Los Angeles, California
  • Takeshi Takajo
    Department of Medicine, University of California, School of Medicine, Los Angeles, California
  • Kazuyuki Narimatsu
    Department of Medicine, University of California, School of Medicine, Los Angeles, California
  • Hyder Said
    Department of Medicine, University of California, School of Medicine, Los Angeles, California
  • Ikuo Kato
    Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan
  • Atsukazu Kuwahara
    Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Japan
  • Jonathan D. Kaunitz
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California

抄録

<jats:p> We report direct in vivo confirmation of transcellular lipopolysaccharides (LPS) uptake from the intestine into the portal vein (PV) involving CD36 and lipid rafts, with minor uptake via the canonical chylomicron pathway. The gut hormone glucagon-like peptide-2 (GLP-2) inhibited uptake into the PV. These data suggest that the bulk of LPS absorption is via the PV to the liver, helping clarify the mechanism of LPS transport into the PV as part of the “gut-liver” axis. These data do not support the paracellular transport of LPS, which has been implicated in the pathogenesis of the “leaky gut” syndrome. </jats:p>

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