Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

DOI Web Site 2 Citations 120 References Open Access

Description

<jats:p>The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.</jats:p>

Journal

  • PLOS Pathogens

    PLOS Pathogens 17 (1), e1009220-, 2021-01-21

    Public Library of Science (PLoS)

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