Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness
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- Takeo Yoshikawa
- Department of Pharmacology Tohoku University Graduate School of Medicine Sendai Japan
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- Tadaho Nakamura
- Department of Pharmacology Tohoku University Graduate School of Medicine Sendai Japan
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- Kazuhiko Yanai
- Department of Pharmacology Tohoku University Graduate School of Medicine Sendai Japan
抄録
<jats:sec><jats:label /><jats:p>Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function, this includes the maintenance of wakefulness, appetite regulation and memory retrieval. Since numerous studies have revealed an association between histaminergic dysfunction and diverse neuropsychiatric disorders, such as Alzheimer's disease and schizophrenia, a large number of compounds acting on the brain histamine system have been developed to treat neurological disorders. In 2016, pitolisant, which was developed as a histamine H<jats:sub>3</jats:sub> receptor inverse agonist by Schwartz and colleagues, was launched for the treatment of narcolepsy, emphasising the prominent role of brain histamine on wakefulness. Recent advances in neuroscientific techniques such as chemogenetic and optogenetic approaches have led to remarkable progress in the understanding of histaminergic neural circuits essential for the control of wakefulness. In this review article, we summarise the basic knowledge about the histaminergic nervous system and the mechanisms underlying sleep/wake regulation that are controlled by the brain histamine system.</jats:p></jats:sec><jats:sec><jats:title>LINKED ARTICLES</jats:title><jats:p>This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.4/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.4/issuetoc</jats:ext-link></jats:p></jats:sec>
収録刊行物
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- British Journal of Pharmacology
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British Journal of Pharmacology 178 (4), 750-769, 2020-09-15
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360853567461375616
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- ISSN
- 14765381
- 00071188
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- データソース種別
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- KAKEN