Polymorphonuclear Myeloid-Derived Cells That Contribute to the Immune Paralysis Are Generated in the Early Phase of Sepsis via PD-1/PD-L1 Pathway
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- Xiang Ao
- Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
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- Yue Yang
- Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
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- Takashi Okiji
- Department of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
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- Miyuki Azuma
- Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
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- Shigenori Nagai
- Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
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- Denise Monack
- editor
説明
<jats:p> Immune paralysis is a protracted state of immune suppression following the early/acute inflammatory phase of sepsis. CD11b <jats:sup>+</jats:sup> Gr-1 <jats:sup>+</jats:sup> cells induced during sepsis are heterogeneous myeloid-derived cells (MDCs). </jats:p>
収録刊行物
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- Infection and Immunity
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Infection and Immunity 89 (6), 2021-05-17
American Society for Microbiology