Changes of liver stiffness measured by magnetic resonance elastography during direct‐acting antivirals treatment in patients with chronic hepatitis C
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- Mayu Higuchi
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Nobuharu Tamaki
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Masayuki Kurosaki
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Kento Inada
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Sakura Kirino
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Koji Yamashita
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Yuka Hayakawa
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Shuhei Sekiguchi
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Leona Osawa
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Kenta Takaura
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Chiaki Maeyashiki
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Shun Kaneko
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Yutaka Yasui
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Kaoru Tsuchiya
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Hiroyuki Nakanishi
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Jun Itakura
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
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- Nobuyuki Enomoto
- First Department of Internal Medicine, Faculty of Medicine University of Yamanashi Yamanashi Japan
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- Namiki Izumi
- Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan
説明
<jats:title>Abstract</jats:title><jats:p>Almost all patients achieved sustained virological response (SVR) by direct‐acting antivirals (DAA) therapy, but it is not clear as to what extent DAA therapy affects changes in liver fibrosis after achieving SVR. In this study, we investigated the changes of liver stiffness by magnetic resonance elastogaraphy (MRE) during DAA therapy. A total of 308 patients were enrolled in the study. Liver stiffness was measured twice before and after DAA treatment using MRE and time‐course change of liver stiffness was investigated. The median (interquartile range) values for liver stiffness were 4.2 (3.2–6.1) kPa at baseline and 3.3 (2.6–4.8) kPa at SVR, demonstrating a significant improvement (<jats:italic>p</jats:italic> < .01). A total of 44% of patients had no improvement in liver stiffness despite achieving SVR. In patients with advanced fibrosis (lower level of albumin [Alb] or histological fibrosis stage F4), it was difficult to improve liver stiffness. Except for Alb, there were no blood tests associated with nonimprovement in liver stiffness, making these cases difficult to predict. In conclusion, despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases, especially in patients with advanced fibrosis. In these patients, liver stiffness must be followed even if SVR is obtained.</jats:p>
収録刊行物
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- Journal of Medical Virology
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Journal of Medical Virology 93 (6), 3744-3751, 2020-09-28
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360853567510812160
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- ISSN
- 10969071
- 01466615
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- データソース種別
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- Crossref
- KAKEN