Functional annotation of human long noncoding RNAs via molecular phenotyping

DOI DOI HANDLE HANDLE HANDLE ほか12件をすべて表示 一部だけ表示 研究データあり 被引用文献5件 参考文献61件 オープンアクセス

説明

<jats:p>Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for <jats:italic>ZNF213-AS1</jats:italic> and <jats:italic>lnc-KHDC3L-2</jats:italic>.</jats:p>

収録刊行物

  • Genome Research

    Genome Research 30 (7), 1060-1072, 2020-07

    Cold Spring Harbor Laboratory

被引用文献 (5)*注記

もっと見る

参考文献 (61)*注記

もっと見る

関連研究データ

もっと見る

関連プロジェクト

もっと見る

キーワード

問題の指摘

ページトップへ