Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Differentiation

DOI Web Site PubMed 参考文献46件
  • Daiki Murase
    Biological Science Research, Kao Corporation, Haga 321-3497, Japan
  • Ayumi Kusaka-Kikushima
    Biological Science Research, Kao Corporation, Odawara 250-0002, Japan
  • Akira Hachiya
    Planning and Implementation, Kao Corporation, Haga 321-3497, Japan
  • Rachel Fullenkamp
    Americas Research Laboratories, Kao USA Inc., Cincinnati, OH 45214, USA
  • Anita Stepp
    Americas Research Laboratories, Kao USA Inc., Cincinnati, OH 45214, USA
  • Asuka Imai
    Americas Research Laboratories, Kao USA Inc., Cincinnati, OH 45214, USA
  • Mizuki Ueno
    Biological Science Research, Kao Corporation, Odawara 250-0002, Japan
  • Keigo Kawabata
    Biological Science Research, Kao Corporation, Odawara 250-0002, Japan
  • Yoshito Takahashi
    Biological Science Research, Kao Corporation, Odawara 250-0002, Japan
  • Tadashi Hase
    Core Technology Sector, Kao Corporation, Sumida 131-0044, Japan
  • Atsushi Ohuchi
    Biological Science Research, Kao Corporation, Haga 321-3497, Japan
  • Shuhei Nakamura
    Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Tamotsu Yoshimori
    Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

説明

<jats:p>Autophagy is a membrane traffic system that provides sustainable degradation of cellular components for homeostasis, and is thus considered to promote health and longevity, though its activity declines with aging. The present findings show deterioration of autophagy in association with premature skin aging. Autophagy flux was successfully determined in skin tissues, which demonstrated significantly decreased autophagy in hyperpigmented skin such as that seen in senile lentigo. Furthermore, an exacerbated decline in autophagy was confirmed in xerotic hyperpigmentation areas, accompanied by severe dehydration and a barrier defect, which showed correlations with skin physiological conditions. The enhancement of autophagy in skin ex vivo ameliorated skin integrity, including pigmentation and epidermal differentiation. The present results indicate that the restoration of autophagy can contribute to improving premature skin aging by various intrinsic and extrinsic factors via the normalization of protein homeostasis.</jats:p>

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