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Innate immunity is a late event in the onset of gliadin-specific enteropathy in the HLA-DQ8 mice
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Description
Celiac disease (CD) is a food enteropathy that occurs in genetically susceptible individuals following the ingestion of gluten. Both gluten cytotoxicity and immunity activation play a role in CD pathogenesis; however, the chronological assessment of the different pathogenic mechanisms remains elusive. The models developed so far have only partially addressed this issue. Herein, Ab°DQ8 transgenic mice were administered wheat gliadin and indomethacin for 10 days to induce enteropathy. Gliadin-induced alteration of the small intestinal architecture was associated with increased expression of tissue transglutaminase in the lamina propria and a marked hypoxic environment. Enteropathic mice showed activation of innate immunity, featuring an increase of pro-inflammatory IFN-γ and IL-15 mRNAs, as well as CD11c
Journal
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- Immunobiology
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Immunobiology 225 (3), 151903-, 2020-05
Elsevier BV
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Keywords
- Gene Expression
- Mice, Transgenic
- Celiac disease; Cytotoxicity; Gliadin; Innate immunity; Intestinal mucosa; Transgenic mice.
- Dendritic Cells
- Gliadin
- Immunity, Innate
- Celiac Disease
- Disease Models, Animal
- Mice
- HLA-DQ Antigens
- Intestine, Small
- Animals
- Cytokines
- Humans
- Disease Susceptibility
- Inflammation Mediators
- Intestinal Mucosa
- Biomarkers
Details 詳細情報について
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- CRID
- 1360853567852328832
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- HANDLE
- 20.500.14243/404073
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- ISSN
- 01712985
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- PubMed
- 31928782
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- Article Type
- journal article
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE