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- David Lara-Astiaso
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Assaf Weiner
- Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
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- Erika Lorenzo-Vivas
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Irina Zaretsky
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Diego Adhemar Jaitin
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Eyal David
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Hadas Keren-Shaul
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Alexander Mildner
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Deborah Winter
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Steffen Jung
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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- Nir Friedman
- Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
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- Ido Amit
- Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
抄録
<jats:title>Opening and closing blood enhancers</jats:title> <jats:p> As cells develop and differentiate into different types, the shape and accessibility of their DNA can change. Lara-Astiaso <jats:italic>et al.</jats:italic> studied this phenomenon in blood. They developed a technique that examines a relatively small number of cells to identify the changes that affect DNA during blood development. They found that the DNA of noncoding regions, called enhancers, is set in an open position when cells are undifferentiated and able to take on a variety of roles and gradually closes as cells mature into their final forms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="943" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1256271">943</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 345 (6199), 943-949, 2014-08-22
American Association for the Advancement of Science (AAAS)