Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

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  • E J Bowman
    Department of Biology, University of California, Santa Cruz 95064.
  • A Siebers
    Department of Biology, University of California, Santa Cruz 95064.
  • K Altendorf
    Department of Biology, University of California, Santa Cruz 95064.

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<jats:p>Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast, E1E2 ATPases--e.g., the K+-dependent (Kdp) ATPase from Escherichia coli, the Na+,K+-ATPase from ox brain, and the Ca2+-ATPase from sarcoplasmic reticulum--are moderately sensitive to this inhibitor. Finally, membrane ATPases from Neurospora vacuoles, chromaffin granules, and plant vacuoles are extremely sensitive. From this we conclude that bafilomycin A1 is a valuable tool for distinguishing among the three different types of ATPases and represents the first relatively specific potent inhibitor of vacuolar ATPases.</jats:p>

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