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- Beatriz García-Pinel
- Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain
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- Cristina Porras-Alcalá
- Department of Organic Chemistry, Faculty of Sciences. University of Málaga, 29071 Málaga, Spain
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- Alicia Ortega-Rodríguez
- Department of Organic Chemistry, Faculty of Sciences. University of Málaga, 29071 Málaga, Spain
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- Francisco Sarabia
- Department of Organic Chemistry, Faculty of Sciences. University of Málaga, 29071 Málaga, Spain
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- Jose Prados
- Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain
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- Consolación Melguizo
- Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain
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- Juan M. López-Romero
- Department of Organic Chemistry, Faculty of Sciences. University of Málaga, 29071 Málaga, Spain
書誌事項
- 公開日
- 2019-04-19
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/nano9040638
- 公開者
- MDPI AG
説明
<jats:p>Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue. LBNPs have been extensively assayed in in vitro cancer therapy but also in vivo, with promising results in some clinical trials. This review summarizes the types of LBNPs that have been developed in recent years and the main results when applied in cancer treatment, including essential assays in patients.</jats:p>
収録刊行物
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- Nanomaterials
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Nanomaterials 9 (4), 638-, 2019-04-19
MDPI AG