抄録
<jats:title>Abstract</jats:title><jats:p>Localization of memory CD8<jats:sup>+</jats:sup> T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX<jats:sub>3</jats:sub>CR1 distinguishes memory CD8<jats:sup>+</jats:sup> T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX<jats:sub>3</jats:sub>CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8<jats:sup>+</jats:sup> T cells with effector function. We find CD62L<jats:sup>hi</jats:sup>CX<jats:sub>3</jats:sub>CR1<jats:sup>+</jats:sup> memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX<jats:sub>3</jats:sub>CR1<jats:sup>+</jats:sup> memory CD8<jats:sup>+</jats:sup> T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX<jats:sub>3</jats:sub>CR1-based functional classification will help to resolve the principles of protective CD8<jats:sup>+</jats:sup> T-cell memory.</jats:p>
収録刊行物
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- Nature Communications
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Nature Communications 6 (1), 8306-, 2015-09-25
Springer Science and Business Media LLC