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- Adriana Albini
- 1IRCCS Multimedica, Milan, Italy;
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- Douglas M. Noonan
- 2Università degli Studi dell'Insubria, Varese, Italy; and
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- Nicoletta Ferrari
- 3Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
説明
<jats:title>Abstract</jats:title> <jats:p>By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed “angioprevention.” Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.</jats:p>
収録刊行物
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- Clinical Cancer Research
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Clinical Cancer Research 13 (15), 4320-4325, 2007-08-01
American Association for Cancer Research (AACR)
