Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

  • Judith S. Brand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • Yvonne T. van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • N. Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • Stephen J. Sharp
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
  • Ken K. Ong
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
  • Kay-Tee Khaw
    Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.
  • Eva Ardanaz
    Navarre Public Health Institute, Pamplona, Spain
  • Pilar Amiano
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
  • Heiner Boeing
    Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • Maria-Dolores Chirlaque
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
  • Françoise Clavel-Chapelon
    INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
  • Francesca L. Crowe
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.
  • Blandine de Lauzon-Guillain
    INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
  • Eric J. Duell
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, L'Hospitalet de Lolgbregat, Barcelona, Spain
  • Guy Fagherazzi
    INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
  • Paul W. Franks
    Department of Clinical Sciences, Clinical Research Center, Malmö General Hospital, Lund University, Malmö, Sweden
  • Sara Grioni
    Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.
  • Leif C. Groop
    Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Scania, Lund University, Malmö, Sweden
  • Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
  • Timothy J. Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.
  • Peter M. Nilsson
    Department of Clinical Sciences, University Hospital Scania, Lund University, Malmö, Sweden
  • Kim Overvad
    Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
  • Domenico Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy
  • Salvatore Panico
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  • J. Ramón Quirós
    Consejería de Sanidad, Public Health Directorate, Oviedo-Asturias, Spain
  • Olov Rolandsson
    Department of Public Health and Clinical Medicine, Family Medicine, Umea University, Umea, Sweden
  • Carlotta Sacerdote
    Center for Cancer Prevention (CPO-Piemonte), Torino, Italy
  • María-José Sánchez
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
  • Nadia Slimani
    International Agency for Research on Cancer, Dietary Exposure Assessment Group, Lyon, France
  • Birgit Teucher
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
  • Anne Tjonneland
    Danish Cancer Society Research Center, Strandboulevarden Copenhagen, Denmark
  • Rosario Tumino
    Cancer Registry and Histopathology Unit, “Civile - M.P. Arezzo” Hospital, Azienda Sanitaria Provinciale No. 7, Ragusa, Italy
  • Daphne L. van der A
    National Institute for Public Health and the Environment, Bilthoven, the Netherlands
  • Edith J.M. Feskens
    Section of Nutrition and Epidemiology, Division of Human Nutrition, University of Wageningen, Wageningen, the Netherlands
  • Claudia Langenberg
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
  • Nita G. Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
  • Elio Riboli
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.
  • Nicholas J. Wareham
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.

抄録

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04–1.69), 1.09 (0.90–1.31), 0.97 (0.86–1.10), and 0.85 (0.70–1.03) for women with menopause at ages &lt;40, 40–44, 45–49, and ≥55 years, respectively, relative to those with menopause at age 50–54 years. The HR per SD younger age at menopause was 1.08 (1.02–1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01–1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all &gt; 0.05).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Early menopause is associated with a greater risk of type 2 diabetes.</jats:p> </jats:sec>

収録刊行物

  • Diabetes Care

    Diabetes Care 36 (4), 1012-1019, 2013-03-14

    American Diabetes Association

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