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- Judith S. Brand
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
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- Yvonne T. van der Schouw
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
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- N. Charlotte Onland-Moret
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
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- Stephen J. Sharp
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
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- Ken K. Ong
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
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- Kay-Tee Khaw
- Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.
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- Eva Ardanaz
- Navarre Public Health Institute, Pamplona, Spain
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- Pilar Amiano
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
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- Heiner Boeing
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Maria-Dolores Chirlaque
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
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- Françoise Clavel-Chapelon
- INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
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- Francesca L. Crowe
- Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.
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- Blandine de Lauzon-Guillain
- INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
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- Eric J. Duell
- Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, L'Hospitalet de Lolgbregat, Barcelona, Spain
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- Guy Fagherazzi
- INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France
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- Paul W. Franks
- Department of Clinical Sciences, Clinical Research Center, Malmö General Hospital, Lund University, Malmö, Sweden
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- Sara Grioni
- Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.
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- Leif C. Groop
- Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Scania, Lund University, Malmö, Sweden
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- Rudolf Kaaks
- Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
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- Timothy J. Key
- Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.
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- Peter M. Nilsson
- Department of Clinical Sciences, University Hospital Scania, Lund University, Malmö, Sweden
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- Kim Overvad
- Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
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- Domenico Palli
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy
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- Salvatore Panico
- Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
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- J. Ramón Quirós
- Consejería de Sanidad, Public Health Directorate, Oviedo-Asturias, Spain
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- Olov Rolandsson
- Department of Public Health and Clinical Medicine, Family Medicine, Umea University, Umea, Sweden
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- Carlotta Sacerdote
- Center for Cancer Prevention (CPO-Piemonte), Torino, Italy
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- María-José Sánchez
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain
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- Nadia Slimani
- International Agency for Research on Cancer, Dietary Exposure Assessment Group, Lyon, France
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- Birgit Teucher
- Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
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- Anne Tjonneland
- Danish Cancer Society Research Center, Strandboulevarden Copenhagen, Denmark
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- Rosario Tumino
- Cancer Registry and Histopathology Unit, “Civile - M.P. Arezzo” Hospital, Azienda Sanitaria Provinciale No. 7, Ragusa, Italy
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- Daphne L. van der A
- National Institute for Public Health and the Environment, Bilthoven, the Netherlands
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- Edith J.M. Feskens
- Section of Nutrition and Epidemiology, Division of Human Nutrition, University of Wageningen, Wageningen, the Netherlands
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- Claudia Langenberg
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
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- Nita G. Forouhi
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
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- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.
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- Nicholas J. Wareham
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
抄録
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04–1.69), 1.09 (0.90–1.31), 0.97 (0.86–1.10), and 0.85 (0.70–1.03) for women with menopause at ages <40, 40–44, 45–49, and ≥55 years, respectively, relative to those with menopause at age 50–54 years. The HR per SD younger age at menopause was 1.08 (1.02–1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01–1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Early menopause is associated with a greater risk of type 2 diabetes.</jats:p> </jats:sec>
収録刊行物
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- Diabetes Care
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Diabetes Care 36 (4), 1012-1019, 2013-03-14
American Diabetes Association