Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy
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- Clodagh P. O’Neill
- Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, H91 YR71 Galway, Ireland
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- Róisín M. Dwyer
- Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, H91 YR71 Galway, Ireland
Description
<jats:p>Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.</jats:p>
Journal
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- Cells
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Cells 9 (2), 521-, 2020-02-24
MDPI AG
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Details 詳細情報について
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- CRID
- 1360855568957269120
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- ISSN
- 20734409
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- Data Source
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- Crossref