IgG Antibody 3D Structures and Dynamics

DOI Web Site 6 Citations
  • Jacob White Jay
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
  • Brinkley Bray
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
  • Yaozhi Qi
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
  • Eseosaserea Igbinigie
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
  • Hao Wu
    College of Information Science and Technology, Beijing Normal University, Beijing 100875, China
  • Jinping Li
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
  • Gang Ren
    The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

Description

<jats:p>Antibodies are vital for human health because of their ability to function as nature’s drugs by protecting the body from infection. In recent decades, antibodies have been used as pharmaceutics for targeted therapy in patients with cancer, autoimmune diseases, and cardiovascular diseases. Capturing the dynamic structure of antibodies and characterizing antibody fluctuation is critical for gaining a deeper understanding of their structural characteristics and for improving drug development. Current techniques for studying three-dimensional (3D) structural heterogeneity and variability of proteins have limitations in ascertaining the dynamic structural behavior of antibodies and antibody-antigen complexes. Here, we review current techniques used to study antibody structures with a focus on the recently developed individual-particle electron tomography (IPET) technique. IPET, as a particle-by-particle methodology for 3D structural characterization, has shown advantages in studying structural variety and conformational changes of antibodies, providing direct imaging data for biomolecular engineering to improve development and clinical application of synthetic antibodies.</jats:p>

Journal

  • Antibodies

    Antibodies 7 (2), 18-, 2018-04-19

    MDPI AG

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