Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection
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- S A Dalrymple
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
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- R Slattery
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
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- D M Aud
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
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- M Krishna
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
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- L A Lucian
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
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- R Murray
- Department of Immunology, DNAX Research Institute, Palo Alto, Calfiornia 94304, USA.
抄録
<jats:p>Interleukin-6 (IL-6) is a multipotential cytokine detected in the serum of patients or experimental animals undergoing bacterial sepsis. To date, the role of IL-6 in gram-negative sepsis models has been controversial. We have used IL-6-deficient mice to investigate the role of IL-6 during virulent Escherichia coli infection and in lipopolysaccharide (LPS)-induced mortality. In this report we describe an increased susceptibility of IL-6-deficient mice to E. coli infection in terms of mortality and accumulation of viable bacteria in tissues, indicating a protective role for IL-6 during the immune response against E. coli. In contrast, mortality rates of IL-6-deficient mice and control animals undergoing LPS-induced shock did not differ, indicating that IL-6 was inconsequential for survival in this model. Furthermore, we have shown that neutrophils were crucial for resistance to E. coli in normal mice. IL-6-deficient mice were unable to efficiently induce neutrophilia in the bloodstream immediately following challenge with E. coli, in contrast to a characteristic neutrophilia induced in control animals. Prophylactic treatment of the mutant animals with recombinant IL-6 protein reverted both the deficit of neutrophilia and the accumulation of bacteria in tissues. These data clarify the role of IL-6 as protective in virulent E. coli infection and suggest that the protective effect may be at least partially mediated through neutrophils.</jats:p>
収録刊行物
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- Infection and Immunity
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Infection and Immunity 64 (8), 3231-3235, 1996-08
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1360855569083474048
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- ISSN
- 10985522
- 00199567
- http://id.crossref.org/issn/00199567
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- データソース種別
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- Crossref