Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
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- Mitsuko L. Yamamoto
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Irene Maier
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Angeline Tilly Dang
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- David Berry
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Jared Liu
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Paul M. Ruegger
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Jiue-in Yang
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Phillip A. Soto
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Laura L. Presley
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Ramune Reliene
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Aya M. Westbrook
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Bo Wei
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Alexander Loy
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Christopher Chang
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Jonathan Braun
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- James Borneman
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
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- Robert H. Schiestl
- Authors' Affiliations: 1Department of Pathology and Lab Medicine, David Geffen School of Medicine, 2Department of Environmental Health Science, Fielding School of Public Health, 3Department of Microbiology, Immunology, and Molecular Genetics, University of California; 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles; 5Department of Plant Pathology and Microbiology, University of California, Riverside, California; and 6Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
書誌事項
- 公開日
- 2013-07-15
- DOI
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- 10.1158/0008-5472.can-13-0022
- 公開者
- American Association for Cancer Research (AACR)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Ataxia-telangiectasia is a genetic disorder associated with high incidence of B-cell lymphoma. Using an ataxia-telangiectasia mouse model, we compared lymphoma incidence in several isogenic mouse colonies harboring different bacterial communities, finding that intestinal microbiota are a major contributor to disease penetrance and latency, lifespan, molecular oxidative stress, and systemic leukocyte genotoxicity. High-throughput sequence analysis of rRNA genes identified mucosa-associated bacterial phylotypes that were colony-specific. Lactobacillus johnsonii, which was deficient in the more cancer-prone mouse colony, was causally tested for its capacity to confer reduced genotoxicity when restored by short-term oral transfer. This intervention decreased systemic genotoxicity, a response associated with reduced basal leukocytes and the cytokine-mediated inflammatory state, and mechanistically linked to the host cell biology of systemic genotoxicity. Our results suggest that intestinal microbiota are a potentially modifiable trait for translational intervention in individuals at risk for B-cell lymphoma, or for other diseases that are driven by genotoxicity or the molecular response to oxidative stress. Cancer Res; 73(14); 4222–32. ©2013 AACR.</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 73 (14), 4222-4232, 2013-07-15
American Association for Cancer Research (AACR)
