Association of the <i>HNF1A</i> polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke
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- Yi‐Jiang Zhou
- Department of Cardiology Institute of Cardiovascular Diseases, the First Affiliated Hospital Guangxi Medical University Nanning China
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- Rui‐Xing Yin
- Department of Cardiology Institute of Cardiovascular Diseases, the First Affiliated Hospital Guangxi Medical University Nanning China
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- Shao‐Cai Hong
- Department of Cardiology, Guangxi Provincial Corps Hospital Chinese People's Armed Police Forces Nanning China
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- Qian Yang
- Department of Cardiology Institute of Cardiovascular Diseases, the First Affiliated Hospital Guangxi Medical University Nanning China
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- Xiao‐Li Cao
- Department of Neurology, the First Affiliated Hospital Guangxi Medical University Nanning China
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- Wu‐Xian Chen
- Department of Cardiology Institute of Cardiovascular Diseases, the First Affiliated Hospital Guangxi Medical University Nanning China
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Hepatocyte nuclear factor‐1α gene (<jats:italic>HNF1A</jats:italic>) single nucleotide polymorphisms (SNPs) have been associated with serum lipid traits in several previous genome‐wide association studies. However, little is known about such associations in the Chinese populations. The present study aimed to determine the association of the <jats:italic>HNF1A</jats:italic> rs1169288, rs2259820, rs2464196 and rs2650000 SNPs and serum lipid traits, the risk of coronary artery disease (CAD) and ischemic stroke (IS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The genotypes of the four SNPs in 562 CAD and 521 IS patients, as well as 594 healthy controls, were detected using the Snapshot technology.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The genotype and allele distribution of the four SNPs was not different between controls and CAD or IS patients (<jats:italic>p ></jats:italic> 0.05 for all). rs1169288, rs2259820 and rs2464196 SNPs were significantly associated with serum lipid levels in both controls and CAD patients (<jats:italic>p</jats:italic> < 0.004–0.009). rs2259820 and rs2464196 SNPs were significantly associated with a lower risk of CAD [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.44–0.91, <jats:italic>p</jats:italic> = 0.015 and OR =0.62, 95% CI = 0.43–0.89, <jats:italic>p</jats:italic> = 0.010, respectively]. Significant linkage disequilibrium was noted among the four SNPs (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> > 0.5, <jats:italic>D</jats:italic>′ <jats:italic>></jats:italic> 0.8). The haplotype of rs1169288A‐rs2259820C‐rs2464196G‐rs2650000A was associated with an increased risk of CAD (OR =1.95, 95% CI: 1.13–3.37, <jats:italic>p</jats:italic> = 0.015). Interactions of SNP–SNP (rs1169288–rs2464196–rs2650000) and haplotype–environment on the risk of CAD (A‐C‐G‐A–smoking) or IS (A‐C‐G‐A–sex and A‐T‐A‐C–alcohol consumption) were also observed among these SNPs.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These findings suggest that the <jats:italic>HNF1A</jats:italic> polymorphisms may be the genetic risk factors for CAD and IS.</jats:p></jats:sec>
収録刊行物
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- The Journal of Gene Medicine
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The Journal of Gene Medicine 19 (1-2), 2017-01
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360855569372393472
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- DOI
- 10.1002/jgm.2941
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- ISSN
- 15212254
- 1099498X
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- データソース種別
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- Crossref