Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

  • Irit Reichenstein
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Chen Eitan
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Sandra Diaz-Garcia
    Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.
  • Guy Haim
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Iddo Magen
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Aviad Siany
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Mariah L. Hoye
    Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Natali Rivkin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Beata Toth
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Revital Ravid
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Amitai D. Mandelbaum
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Eran Yanowski
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Jing Liang
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Jeffrey K. Rymer
    Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Rivka Levy
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Gilad Beck
    Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Elena Ainbinder
    Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Sali M. K. Farhan
    Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Kimberly A. Lennox
    Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
  • Nicole M. Bode
    Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
  • Mark A. Behlke
    Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
  • Thomas Möller
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
  • Smita Saxena
    Department of Neurology, Inselspital University Hospital, University of Bern, Freiburgstrasse 16, CH-3010 Bern, Bern, Switzerland.
  • Cristiane A. M. Moreno
    Department of Neurology, Columbia University, New York, NY 10032, USA.
  • Giancarlo Costaguta
    Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Kristel R. van Eijk
    Project MinE ALS Sequencing Consortium.
  • Hemali Phatnani
    Center for Genomics of Neurodegenerative Disease (CGND) and New York Genome Center (NYGC) ALS Consortium, New York, NY 10013, USA.
  • Ammar Al-Chalabi
    Project MinE ALS Sequencing Consortium.
  • A. Nazli Başak
    Project MinE ALS Sequencing Consortium.
  • Leonard H. van den Berg
    Project MinE ALS Sequencing Consortium.
  • Orla Hardiman
    Project MinE ALS Sequencing Consortium.
  • John E. Landers
    Project MinE ALS Sequencing Consortium.
  • Jesus S. Mora
    Project MinE ALS Sequencing Consortium.
  • Karen E. Morrison
    Project MinE ALS Sequencing Consortium.
  • Pamela J. Shaw
    Project MinE ALS Sequencing Consortium.
  • Jan H. Veldink
    Project MinE ALS Sequencing Consortium.
  • Samuel L. Pfaff
    Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Ofer Yizhar
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Christina Gross
    Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Robert H. Brown
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • John M. Ravits
    Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.
  • Matthew B. Harms
    Department of Neurology, Columbia University, New York, NY 10032, USA.
  • Timothy M. Miller
    Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Eran Hornstein
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.

この論文をさがす

説明

<jats:p>Genetics, pathology, and molecular studies demonstrate that microRNA-218 is modulated and might play a role in amyotrophic lateral sclerosis.</jats:p>

収録刊行物

  • Science Translational Medicine

    Science Translational Medicine 11 (523), eaav5264-, 2019-12-18

    American Association for the Advancement of Science (AAAS)

被引用文献 (2)*注記

もっと見る

問題の指摘

ページトップへ