Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology
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- Irit Reichenstein
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Chen Eitan
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Sandra Diaz-Garcia
- Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.
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- Guy Haim
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Iddo Magen
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Aviad Siany
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Mariah L. Hoye
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Natali Rivkin
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Tsviya Olender
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Beata Toth
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Revital Ravid
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Amitai D. Mandelbaum
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Eran Yanowski
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Jing Liang
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Jeffrey K. Rymer
- Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
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- Rivka Levy
- Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Gilad Beck
- Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Elena Ainbinder
- Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Sali M. K. Farhan
- Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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- Kimberly A. Lennox
- Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
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- Nicole M. Bode
- Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
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- Mark A. Behlke
- Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.
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- Thomas Möller
- Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
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- Smita Saxena
- Department of Neurology, Inselspital University Hospital, University of Bern, Freiburgstrasse 16, CH-3010 Bern, Bern, Switzerland.
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- Cristiane A. M. Moreno
- Department of Neurology, Columbia University, New York, NY 10032, USA.
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- Giancarlo Costaguta
- Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Kristel R. van Eijk
- Project MinE ALS Sequencing Consortium.
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- Hemali Phatnani
- Center for Genomics of Neurodegenerative Disease (CGND) and New York Genome Center (NYGC) ALS Consortium, New York, NY 10013, USA.
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- Ammar Al-Chalabi
- Project MinE ALS Sequencing Consortium.
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- A. Nazli Başak
- Project MinE ALS Sequencing Consortium.
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- Leonard H. van den Berg
- Project MinE ALS Sequencing Consortium.
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- Orla Hardiman
- Project MinE ALS Sequencing Consortium.
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- John E. Landers
- Project MinE ALS Sequencing Consortium.
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- Jesus S. Mora
- Project MinE ALS Sequencing Consortium.
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- Karen E. Morrison
- Project MinE ALS Sequencing Consortium.
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- Pamela J. Shaw
- Project MinE ALS Sequencing Consortium.
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- Jan H. Veldink
- Project MinE ALS Sequencing Consortium.
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- Samuel L. Pfaff
- Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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- Ofer Yizhar
- Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
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- Christina Gross
- Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
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- Robert H. Brown
- Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
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- John M. Ravits
- Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.
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- Matthew B. Harms
- Department of Neurology, Columbia University, New York, NY 10032, USA.
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- Timothy M. Miller
- Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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- Eran Hornstein
- Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
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説明
<jats:p>Genetics, pathology, and molecular studies demonstrate that microRNA-218 is modulated and might play a role in amyotrophic lateral sclerosis.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 11 (523), eaav5264-, 2019-12-18
American Association for the Advancement of Science (AAAS)