Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease

  • Hasan Kaya
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Faruk Ertaş
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Yahya İslamoğlu
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Zekeriya Kaya
    Department of Cardiology, Harran University Faculty of Medicine, Şanlıurfa, Turkey
  • Zuhal Arıtürk Atılgan
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Habib Çil
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Ahmet Çalışkan
    Department of Cardiovascular Surgery, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Mesut Aydın
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Mustafa Oylumlu
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
  • Mehmet Serdar Soydinç
    Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey

Description

<jats:p> The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups ( P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease. </jats:p>

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