The LIM homeobox gene<i>Isl1</i>is required for the correct development of the striatonigral pathway in the mouse
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- Lisa A. Ehrman
- Divisions of aDevelopmental Biology,
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- Xiuqian Mu
- Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston TX 77030; and
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- Ronald R. Waclaw
- Experimental Hematology and Cancer Biology and
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- Yutaka Yoshida
- Divisions of aDevelopmental Biology,
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- Charles V. Vorhees
- Neurology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati OH 45229;
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- William H. Klein
- Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston TX 77030; and
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- Kenneth Campbell
- Divisions of aDevelopmental Biology,
説明
<jats:title>Significance</jats:title><jats:p>The basal ganglia process cortical information that controls purposeful movements and appropriate behavior via the striatopallidal and striatonigral pathways. Despite their importance, little is known about the developmental mechanisms that control the formation of these pathways. We show here that telencephalic progenitors expressing the transcription factor Islet1 give rise to striatonigral neurons and that this factor is required for normal development of the striatonigral pathway. Moreover, Islet1 mouse mutants exhibit hyperactivity and a paradoxical response to psychostimulants. Given that the underlying causes of basal ganglia disorders such as attention deficit hyperactivity disorder (ADHD) are unknown, these findings may implicate possible alterations in neural circuitry.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (42), E4026-, 2013-09-30
Proceedings of the National Academy of Sciences