Kidney malformations in fetuses of A × C line 9935 rats

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<jats:title>Abstract</jats:title><jats:p>Fifty A × C 9935 strain inbred rat litters were examined near term; 88/315 fetuses (27.9%) showed renal malformations (renal agenesis and hydronephrosis). Unilateral renal agenesis occurred more often on the right side (11.5%) than the left (3.6%), especially in males. Renal agenesis was always associated with absence or hypoplasia of a uterine horn or vas deferens and epididymis on the corresponding side. However, the ovaries or testes were present and intact. Hydronephrosis was seen more often on the left side (11.4%) than the right (3.5%). There was no significant sex difference in the frequency of renal agenesis and hydronephrosis. In hydronephrosis the ureteropelvic junction was patent, and hydroureter always accompanied moderate hydronephrosis. Atresia near the vesicoureteral junction was considered as a cause of hydronephrosis. There was a close morphogenetic relation between renal agenesis and hydronephrosis.</jats:p>

Journal

  • Teratology

    Teratology 3 (3), 245-249, 1970-08

    Wiley

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